Prevention of vaginal SHIV transmission in macaques by a live recombinant Lactobacillus.

by Osel | Nov 1, 2011 | MUCOCEPT

Lagenaur, LA, Sanders-Beer, BE, Brichacek, B, Pal R, Liu X, Liu, Y, Venzon, D, Lee, PP, Hamer, DH. Mucosal Immunol. 2011 Nov;4(6):648-57. doi: 10.1038/mi.2011.30. Epub 2011 Jul 6.     Synopsis: The rhesus macaque model was used to examine proof of concept...

Engineering of Lactobacillus jensenii to secrete RANTES and a CCR5 antagonist analogue as live HIV-1 blockers.

by Osel | Jul 1, 2010 | MUCOCEPT

Vangelista, L, Secchi, M, Liu, X, Bachi, A, Xu, Q, Lusso, P. Antimicrob Agents Chemother. 2010 Jul;54(7):2994-3001. doi: 10.1128/AAC.01492-09. Epub 2010 May 17.     Synopsis: Proof of concept for the use of Lactobacillus jensenii-produced C1C5 RANTES to...

The superior folding of a RANTES analogue expressed in lactobacilli as compared to mammalian cells reveals a promising system to screen new RANTES mutants.

by Osel | Nov 1, 2009 | MUCOCEPT

Secchi, M, Xu, Q, Lusso, P, and Vangelista, L. Protein Expr Purif. 2009 Nov;68(1):34-41. doi: 10.1016/j.pep.2009.06.018. Epub 2009 Jun 30.     Synopsis: RANTES is a natural protein expressed on activated T cells; one of the activities of RANTES is to bind to...

A Chinese rhesus macaque (Macaca mulatta) model for vaginal Lactobacillus colonization and live microbicide development.

by Osel | Apr 1, 2009 | MUCOCEPT

Yu, RR, Cheng, AT, Lagenaur, LA, Huang, W, Weiss, DE, Treece, J, Sanders-Beer, BE, Hamer, DH, Lee, PP, Xu, Q and Liu, Y. J Med Primatol. 2009 Apr;38(2):125-36.     Synopsis: In order to test Osel’s engineered live biotherapeutic, which contains a live human...

Engineering of a human vaginal Lactobacillus strain for surface expression of two-domain CD4 molecules.

by Osel | Aug 1, 2008 | MUCOCEPT

Liu, X, Lagenaur, LA, Lee, PP, Xu, Q. Appl Environ Microbiol. 2008 Aug;74(15):4626-35. doi: 10.1128/AEM.00104-08. Epub 2008     Synopsis: The primary receptor for HIV-1 is CD4, which is normally found on CD4+ T cells. Osel identified native surface proteins...

Engineering vaginal Lactobacillus strain for mucosal delivery of the human immunodeficiency virus inhibitor cyanovirin-N.

by Osel | Oct 1, 2006 | MUCOCEPT

Liu X, Lagenaur LA, Simpson DA, Essenmacher, KP, Frazier-Parker, CL, Liu, Y, Tsai, D, Rao, SS, Hamer, DH, Parks, TP, Lee, PP, Xu, Q. Antimicrob Agents Chemother. 2006 Oct;50(10):3250-9.     Synopsis: Cyanovirin-N (CV-N) is a small protein that was originally...