Yu, RR, Cheng, AT, Lagenaur, LA, Huang, W, Weiss, DE, Treece, J, Sanders-Beer, BE, Hamer, DH, Lee, PP, Xu, Q and Liu, Y. J Med Primatol. 2009 Apr;38(2):125-36.



Synopsis: In order to test Osel’s engineered live biotherapeutic, which contains a live human vaginal Lactobacillus bacterium, an appropriate animal model needed to be established. The rhesus macaque is commonly used in HIV studies, and has low levels of Lactobacillus spp. in its vaginal microbiome. We tested and confirmed that the model supported vaginal colonization with L. jensenii, L. crispatus, and L. gasseri.