The Atlantic Explores the Scourge of Bacterial Vaginosis

by Osel | Jan 23, 2018 | announcements, Featured, LACTIN-V, MUCOCEPT

It’s the most common vaginal infection you’ve probably never heard of: Bacterial vaginosis (BV). It’s the culprit that causes embarrassing odors and discharge, and the reason many women visit their gynecologist. Nearly one-third of U.S. women of reproductive age have...

Expression of HIV-1 Neutralizing Antibody Fragments Using Human Vaginal Lactobacillus

by Osel | Mar 7, 2016 | MUCOCEPT

Marcobal A, Liu X, Zhang W, Dimitrov A, Jia L, Lee PP, Fouts T, Parks TP, Lagenaur LA. AIDS Res Hum Retroviruses. 2016 Mar 7.     Synopsis: These studies demonstrate that a human vaginal commensal bacteria Lactobacillus, L. jensenii is able express an...

Robust vaginal colonization of macaques with a novel vaginally disintegrating tablet containing a live biotherapeutic product to prevent HIV infection in women.

by Osel | Apr 14, 2015 | MUCOCEPT

Lagenaur, LA, Swedek, I, Lee, PP, Parks, TP. PLoS One. 2015 Apr 14;10(4):e0122730. doi:  0.1371/journal.pone.0122730..     Synopsis: Lactobacillus jensenii engineered to secrete modified cyanovirin-N was formulated as a vaginally disintegrating tablet and...

In vivo evaluation of safety and toxicity of a Lactobacillus jensenii producing modified cyanovirin-N in a rhesus macaque vaginal challenge model.

by Osel | Nov 12, 2013 | MUCOCEPT

Brichacek B, Lagenaur, LA, Lee, PP, Venzon, D, Hamer, DH. PLoS One. 2013 Nov 12;8(11):e78817. doi: 10.1371/journal.pone.0078817.     Synopsis: A preclinical safety study was performed in macaques colonized with Lactobacillus jensenii engineered to secrete...

Homeostatic properties of Lactobacillus jensenii engineered as a live vaginal anti-HIV microbicide.

by Osel | Jan 8, 2013 | MUCOCEPT

Yamamoto, HS, Xu, Q and Fichorova, RN BMC Microbiol. 2013 Jan 8;13:4. doi: 10.1186/1471-2180-13-4.     Synopsis: Preclinical studies of Osel’s engineered live biotherapeutic for prevention of HIV infection in women demonstrated successful in vitro production...

Demonstration of vaginal colonization with GusA-expressing Lactobacillus jensenii following oral delivery in rhesus macaques.

by Osel | Dec 1, 2011 | MUCOCEPT

Lagenaur, LA, Lee, PP, Hamer, DH, Sanders-Beer, BE. Res Microbiol. 2011 Dec;162(10):1006-10. doi: 10.1016/j.resmic.2011.08.003. Epub 2011 Aug 29.     Synopsis: It has been postulated that the rectal microbiome serves as a reservoir for the vaginal...