Marcobal A, Liu X, Zhang W, Dimitrov A, Jia L, Lee PP, Fouts T, Parks TP, Lagenaur LA. AIDS Res Hum Retroviruses. 2016 Mar 7.



Synopsis: These studies demonstrate that a human vaginal commensal bacteria Lactobacillus, L. jensenii is able express an anti-HIV antibody fragment.  The antibody fragment, m36.4, binds to a region on gp120 called the CD4-induced region and has potency and breadth against numerous HIV-1 envelopes.  We made a stable recombinant L. jensenii 1153-1128 that constitutively expresses m36.4. Delivery of anti-HIV-1 antibodies by Lactobacillus could provide passive transfer of these antibodies to the mucosa and longevity at the site of transmission.