Phase 1 dose-ranging safety trial of Lactobacillus crispatus CTV-05 for the prevention of bacterial vaginosis.

by Osel | Sep 1, 2009 | LACTIN-V CLINICAL

Hemmerling, A, Harrison, W, Schroeder, A, Park, J, Korn, A, Shiboski, S and Cohen, CR. Sex Transm Dis. 2009 Sep;36(9):564-9. doi: 10.1097/OLQ.0b013e3181a74924.     Synopsis: LACTIN-V at three dose levels was tested using a proprietary vaginal applicator in a...

Vaginal colonization by probiotic Lactobacillus crispatus CTV-05 is decreased by sexual activity and endogenous Lactobacilli.

by Osel | May 15, 2009 | LACTIN-V CLINICAL

Antonio MA1, Meyn LA, Murray PJ, Busse B, Hillier SL. J Infect Dis. 2009 May 15;199(10):1506-13. doi: 10.1086/598686.     Synopsis: Sexually active females aged 14-21 years were randomized to receive either 106 or 108 colony forming units (CFU) CTV-05...

A Chinese rhesus macaque (Macaca mulatta) model for vaginal Lactobacillus colonization and live microbicide development.

by Osel | Apr 1, 2009 | MUCOCEPT

Yu, RR, Cheng, AT, Lagenaur, LA, Huang, W, Weiss, DE, Treece, J, Sanders-Beer, BE, Hamer, DH, Lee, PP, Xu, Q and Liu, Y. J Med Primatol. 2009 Apr;38(2):125-36.     Synopsis: In order to test Osel’s engineered live biotherapeutic, which contains a live human...

Engineering of a human vaginal Lactobacillus strain for surface expression of two-domain CD4 molecules.

by Osel | Aug 1, 2008 | MUCOCEPT

Liu, X, Lagenaur, LA, Lee, PP, Xu, Q. Appl Environ Microbiol. 2008 Aug;74(15):4626-35. doi: 10.1128/AEM.00104-08. Epub 2008     Synopsis: The primary receptor for HIV-1 is CD4, which is normally found on CD4+ T cells. Osel identified native surface proteins...

Efficacy of Clostridium butyricum preparation concomitantly with Helicobacter pylori eradication therapy in relation to changes in the intestinal microbiota.

by Osel | Mar 19, 2008 | CBM588 CLINICAL

Imase K, Takahashi M, Tanaka A, Tokunaga K, Sugano H, Tanaka M, Ishida H, Kamiya S, Takahashi S. Microbiol Immunol. 2008 Mar;52(3):156-61. doi: 10.1111/j.1348-0421.2008.00026.x.     Synopsis: Antibiotic associated diarrhea due to human intestinal microbiota...