Homeostatic properties of Lactobacillus jensenii engineered as a live vaginal anti-HIV microbicide.

by Osel | Jan 8, 2013 | MUCOCEPT

Yamamoto, HS, Xu, Q and Fichorova, RN BMC Microbiol. 2013 Jan 8;13:4. doi: 10.1186/1471-2180-13-4.     Synopsis: Preclinical studies of Osel’s engineered live biotherapeutic for prevention of HIV infection in women demonstrated successful in vitro production...

Effect of probiotics on serum bile acids in patients with ulcerative colitis.

by Osel | Sep 19, 2012 | CBM588 CLINICAL

Sato S, Nagai H, Igarashi Y. Hepatogastroenterology. 2012 Sep;59(118):1804-8.     Synopsis: During enterohepatic circulation, the intestinal microbiota causes 7 alpha-dehydroxylation of cholic acid (CA) and chenodeoxycholic acid (CDCA), yielding deoxycholic...

Demonstration of vaginal colonization with GusA-expressing Lactobacillus jensenii following oral delivery in rhesus macaques.

by Osel | Dec 1, 2011 | MUCOCEPT

Lagenaur, LA, Lee, PP, Hamer, DH, Sanders-Beer, BE. Res Microbiol. 2011 Dec;162(10):1006-10. doi: 10.1016/j.resmic.2011.08.003. Epub 2011 Aug 29.     Synopsis: It has been postulated that the rectal microbiome serves as a reservoir for the vaginal...

Prevention of vaginal SHIV transmission in macaques by a live recombinant Lactobacillus.

by Osel | Nov 1, 2011 | MUCOCEPT

Lagenaur, LA, Sanders-Beer, BE, Brichacek, B, Pal R, Liu X, Liu, Y, Venzon, D, Lee, PP, Hamer, DH. Mucosal Immunol. 2011 Nov;4(6):648-57. doi: 10.1038/mi.2011.30. Epub 2011 Jul 6.     Synopsis: The rhesus macaque model was used to examine proof of concept...

Effects of bacterial vaginosis-associated bacteria and sexual intercourse on vaginal colonization with the probiotic Lactobacillus crispatus CTV-05

by Osel | Nov 1, 2011 | LACTIN-V CLINICAL

Ngugi, BM, Hemmerling, A, Bukusi, EA, Kikuvi, G, Gikunju, JShiboski, S, Frederick, DN, and Cohen, CR. Sex Transm Dis. 2011 Nov;38(11):1020-7. doi: 10.1097/OLQ.0b013e3182267ac4.     Synopsis: In the LACTIN-V Phase 2a BV study, colonization with L. crispatus...