Ngugi, BM, Hemmerling, A, Bukusi, EA, Kikuvi, G, Gikunju, JShiboski, S, Frederick, DN, and Cohen, CR. Sex Transm Dis. 2011 Nov;38(11):1020-7. doi: 10.1097/OLQ.0b013e3182267ac4.
Synopsis: In the LACTIN-V Phase 2a BV study, colonization with L. crispatus CTV-05 was associated with increased L. crispatus levels and decreased levels of BV-associated bacteria as determined by quantitative PCR. Conversely, women who experienced BV treatment failures with metronidazole, did not colonize with CTV-05 and exhibited low levels of L. crispatus and high levels of BV-associated bacteria. In addition, the presence of endogenous L. crispatus at enrollment and vaginal sexual intercourse during treatment with LACTIN-V significantly impaired colonization of CTV-05.