Lactobacillus crispatus capsules: single-use safety study in the Macaca nemestrina model.

Patton DL, Cosgrove Sweeney YT, Antonio MA, Rabe LK, Hillier SL. Sex Transm Dis. 2003 Jul;30(7):568-70.

Synopsis: A single intravaginal application of capsules containing 10⁸ colony forming units (CFU) of L crispatus CTV-05 resulted in vaginal colonization in 3 of 10 animals 2 days after use. The absence of colposcopic changes in the vagina/cervical tissues indicates that L crispatus capsules are well tolerated.