Safety assessment of the Clostridium butyricum MIYAIRI 588® probiotic strain including evaluation of antimicrobial sensitivity and presence of Clostridium toxin genes in vitro and teratogenicity in vivo.

by Osel | Oct 5, 2015 | CBM588

Isa K, Oka K, Beauchamp N, Sato M, Wada K, Ohtani K, Nakanishi S, McCartney E, Tanaka M, Shimizu T, Kamiya S, Kruger C, Takahashi M. Hum Exp Toxicol. 2015 Oct 5. pii: 0960327115607372. [Epub ahead of print]     Synopsis: Development of new live...

Smad2 and Smad3 Inversely Regulate TGF-β Autoinduction in Clostridium butyricum-Activated Dendritic Cells.

by Osel | Jul 21, 2015 | CBM588

Kashiwagi I, Morita R, Schichita T, Komai K, Saeki K, Matsumoto M, Takeda K, Nomura M, Hayashi A, Kanai T, Yoshimura A. Immunity. 2015 Jul 21;43(1):65-79. doi: 10.1016/j.immuni.2015.06.010. Epub 2015 Jun 30.     Synopsis: Colonization with a mixture of...

A breakthrough in probiotics: Clostridium butyricum regulates gut homeostasis and anti-inflammatory response in inflammatory bowel disease.

by Osel | May 2, 2015 | CBM588

Kanai T, Mikami Y, Hayashi A. J Gastroenterol. 2015 Sep;50(9):928-39. doi: 10.1007/s00535-015-1084-x. Epub 2015 May 5.     Synopsis: Intestinal immune homeostasis is regulated by gut microbiota, including beneficial and pathogenic microorganisms. Imbalance...

Clostridium butyricum MIYAIRI 588 improves high-fat diet-induced non-alcoholic fatty liver disease in rats.

by Osel | Oct 29, 2013 | CBM588

Seo M, Inoue I, Tanaka M, Matsuda N, Nakano T, Awata T, Katayama S, Alpers DH, Komoda T. Dig Dis Sci. 2013 Dec;58(12):3534-44. doi: 10.1007/s10620-013-2879-3. Epub 2013 Oct 29.     Synopsis: The aim of this study was to examine the effect of Clostridium...

A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice.

by Osel | Jun 12, 2013 | CBM588

Hayashi A, Sato T, Kamada N, Mikami Y, Matsuoka K, Hisamatsu T, Hibi T, Roers A, Yagita H, Ohteki T, Yoshimura A, Kanai T. Cell Host Microbe. 2013 Jun 12;13(6):711-22. doi: 10.1016/j.chom.2013.05.013.     Synopsis: Imbalance in gut bacterial composition...

Clostridium butyricum MIYAIRI 588 shows antitumor effects by enhancing the release of TRAIL from neutrophils through MMP-8.

by Osel | Jan 23, 2013 | CBM588

Shinnoh M, Horinaka M, Yasuda T, Yoshikawa S, Morita M, Yamada T, Miki T, Sakai T. Int J Oncol. 2013 Mar;42(3):903-11. doi: 10.3892/ijo.2013.1790. Epub 2013 Jan 23     Synopsis: Bacillus Calmette-Guérin (BCG) intravesical therapy against superficial bladder...