Robust vaginal colonization of macaques with a novel vaginally disintegrating tablet containing a live biotherapeutic product to prevent HIV infection in women.

by Osel | Apr 14, 2015 | MUCOCEPT

Lagenaur, LA, Swedek, I, Lee, PP, Parks, TP. PLoS One. 2015 Apr 14;10(4):e0122730. doi:  0.1371/journal.pone.0122730..     Synopsis: Lactobacillus jensenii engineered to secrete modified cyanovirin-N was formulated as a vaginally disintegrating tablet and...

In vivo evaluation of safety and toxicity of a Lactobacillus jensenii producing modified cyanovirin-N in a rhesus macaque vaginal challenge model.

by Osel | Nov 12, 2013 | MUCOCEPT

Brichacek B, Lagenaur, LA, Lee, PP, Venzon, D, Hamer, DH. PLoS One. 2013 Nov 12;8(11):e78817. doi: 10.1371/journal.pone.0078817.     Synopsis: A preclinical safety study was performed in macaques colonized with Lactobacillus jensenii engineered to secrete...

Clostridium butyricum MIYAIRI 588 improves high-fat diet-induced non-alcoholic fatty liver disease in rats.

by Osel | Oct 29, 2013 | CBM588

Seo M, Inoue I, Tanaka M, Matsuda N, Nakano T, Awata T, Katayama S, Alpers DH, Komoda T. Dig Dis Sci. 2013 Dec;58(12):3534-44. doi: 10.1007/s10620-013-2879-3. Epub 2013 Oct 29.     Synopsis: The aim of this study was to examine the effect of Clostridium...

A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice.

by Osel | Jun 12, 2013 | CBM588

Hayashi A, Sato T, Kamada N, Mikami Y, Matsuoka K, Hisamatsu T, Hibi T, Roers A, Yagita H, Ohteki T, Yoshimura A, Kanai T. Cell Host Microbe. 2013 Jun 12;13(6):711-22. doi: 10.1016/j.chom.2013.05.013.     Synopsis: Imbalance in gut bacterial composition...

Clostridium butyricum MIYAIRI 588 shows antitumor effects by enhancing the release of TRAIL from neutrophils through MMP-8.

by Osel | Jan 23, 2013 | CBM588

Shinnoh M, Horinaka M, Yasuda T, Yoshikawa S, Morita M, Yamada T, Miki T, Sakai T. Int J Oncol. 2013 Mar;42(3):903-11. doi: 10.3892/ijo.2013.1790. Epub 2013 Jan 23     Synopsis: Bacillus Calmette-Guérin (BCG) intravesical therapy against superficial bladder...