Yasueda A, Mizushima T, Nezu R, Sumi R, Tanaka M, Nishimura J, Kai Y, Hirota M, Osawa H, Nakajima K, Mori M, Ito T.
Synopsis: A randomized, placebo-controlled study was performed on 17 patients with ulcerative colitis who had under gone ileal pouch anal anastomosis (IPAA). Pouchitis is one of the most common long-term complications after IPAA. Nine tablets of MIYA-BM® or placebo were orally administered once daily. One of nine subjects in the MIYA-BM group (11%) and four of eight subjects in the placebo group (50%) developed pouchitis. No side effects occurred in either group. Characteristic intestinal flora was observed in each group with obligate anaerobes higher in the MIYA-BM group. The results suggested that CBM588 might be a useful complementary therapy with minimal side effects for the prevention of pouchitis in patients with UC who have undergone IPAA.