Seo M, Inoue I, Tanaka M, Matsuda N, Nakano T, Awata T, Katayama S, Alpers DH, Komoda T. Dig Dis Sci. 2013 Dec;58(12):3534-44. doi: 10.1007/s10620-013-2879-3. Epub 2013 Oct 29.
Synopsis: The aim of this study was to examine the effect of Clostridium butyricum MIYAIRI 588 (CBM588) on high-fat diet (HFD)-induced fatty liver in rats. The HFD-CBM group had decreased accumulation of lipid droplets in the liver compared with the HFD group. The HFD-CBM group had significantly decreased diacylglycerol acyltransferase (DGAT) 2 mRNA in the liver compared with the HFD group, whereas DGAT1 mRNA did not change between the HFD group and the HFD-CBM group. Moreover, the HFD-CBM group had significantly increased hepatic mRNA regulating cholesterol catabolism enzymes and excretion transporters. Correspondingly, the HFD-CBM588 groups had increased hepatic protein levels of peroxisome proliferator-activated receptor α/γ and liver X receptor α compared with the HFD group. The HFD-CBM group had accelerated excretion of total bile acid and non-esterified fatty acid in the feces. CBM588 may have novel potential for improving NAFLD.